donderdag 12 februari 2009

Engineering a multi-functional probiotic

A team of students has designed a probiotic bacterium that can exhibit four different health-promoting functions inside the human gut. The students recently won a prize for this achievement at a prestigious international competition. Their results could help pave the way for ‘synthetic probiotics’.

Designing an organism at the drawing table, working with the desired functions as a starting point, and then building that organism just like an engineer builds a bridge or a building... It sounds like science fiction, but it is in fact almost a reality. Called ‘synthetic biology’, this principle is rapidly gaining its place in the world of genetic engineering. Its pioneers are using standardized DNA building blocks, or biobricks, which are either isolated from existing organisms or synthetized in a lab. Making rganisms from scratch may not yet be possible, but scientists are already building entirely new metabolic circuits – which is taking ‘regular’ genetic engineering one step further.
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